April 2018 CME Article No. 4: Limbic and Basal Ganglia Neuroanatomical Correlates of Gait and Executive Function: Older Adults With Mild Cognitive Impairment and Intact Cognition

Additional Information

Objective:
This study aimed to examine differences in spatiotemporal gait parameters between older adults with amnestic mild cognitive impairment (aMCI) and normal cognition (NC), and to examine limbic and basal ganglia neural correlates of gait and executive function in older adults without dementia.

Design:
This was a cross sectional study of 46 community dwelling older adults, ages 70-95 with aMCI (n=23) and NC (n=23). Structural magnetic resonance imaging (MRI) was used to attain volumetric measures of limbic and basal ganglia structures. Quantitative motion analysis was used to measure spatiotemporal parameters of gait. The Trail Making Test was used to assess executive function.

Results:
During fast paced walking, older adults with aMCI demonstrated significantly slower gait speed and shorter stride length compare to older adults with NC. Stride length was positively correlated with hippocampal, anterior cingulate, and nucleus accumbens volumes (P < 0.05). Executive function was positively correlated with hippocampal, anterior cingulate, and posterior cingulate volumes (P < 0.05).

Conclusions:
Compared to older adults with NC, those with aMCI demonstrated slower gait speed and shorter stride length, during fast-pace walking, and lower executive function. Hippocampal and anterior cingulate volumes demonstrated moderate positive correlation with both gait and executive function, after adjusting for age.

Learning Objectives:

Discuss gait performance and cognitive function in older adults with aMCI (amnestic mild cognitive impairment)versus normal cognition
Discuss neurocorrelates of gait and executive function in older adults without dementia
Recognize the importance of assessing gait speed and cognitive function in the clinical management of older adults at risk for dementia

Summary


Availability:	On-Demand


Cost:	Member: $0.00 Non-Member: $15.00 Resident Member: $0.00 Resident Non-Member: $15.00


Credit Offered:	0.5 CME Credit

Recommended

January 2018 CME Article No. 1: Cardiovascular Monitoring During Video Urodynamic Studies in Persons with Spinal Cord Injury

0.5 CME

$0.00 - $15.00

February 2018 CME Article No. 2: Alterations in the Mechanical Response of Deep Dorsal Neck Muscles in Individuals Experiencing Whiplash-Associated Disorders Compared to Healthy Controls

0.5 CME

$0.00 - $15.00

June 2018 CME Article No. 6 Automated Mechanical Peripheral Stimulation Improves Gait Parameters in Subjects With Parkinson Disease and Freezing of Gait: A Randomized Clinical Trial

0.5 CME

$0.00 - $15.00

July 2018 CME Activity No. 7: Acute-Phase Predictors of 6-Month Functional Outcome in Italian Stroke Patients Eligible for In-Hospital Rehabilitation

1 CME

$0.00 - $15.00

August 2018 CME Article No. 8 The Effects of a Motorized Aquatic Treadmill Exercise Program on Muscle Strength, Cardiorespiratory Fitness, and Clinical Function in Subacute Stroke Patients

1 CME

$0.00 - $15.00

March 2018 CME Article No. 3:Trunk Exercises Improve Gait Symmetry in Parkinson Disease: A Blind Phase II Randomized Controlled Trial

0.5 CME

$0.00 - $15.00

May 2018 CME Article No. 5: The Link Between Cerebrovascular Hemodynamics and Rehabilitation Outcomes After Aneurysmal Subarachnoid Hemorrhage

0.5 CME

$0.00 - $15.00

September 2018 CME Activity No. 9: Efficacy of Extracorporeal Shock Wave Therapy for Lower Extremity Tendinopathy: A Meta-analysis of Randomised Controlled Trials

1 CME

$0.00 - $15.00

December 2018 CME Activity No. 12: Co-morbidities Associated With Early Mortality in Adults With Spina Bifida

1 CME

$0.00 - $15.00

January 2019 CME Activity: Fatigue After Aneurysmal Subarachnoid Hemorrhage Is Highly Prevalent in the First-Year Postonset and Related to Low Physical Fitness

1 CME

$0.00 - $15.00