Orthobiologics & Regenerative Medicine Series: Muscle Regeneration presented by Andrea Domenighetti, PhD-Muscle Regeneration

Video Transcription

Video Summary

In this video, Dr. Dhammageddy discusses the treatment of muscle and motor dysfunction in children with cerebral palsy. He focuses on the potential of activating the resident muscles themselves to treat muscle impairment in these patients. Dr. Dhammageddy explains that satellite cells, which are muscle stem cells, play a critical role in postnatal muscle development and repair. He discusses the impairments in satellite cell function seen in children with cerebral palsy, including reduced satellite cell numbers and impaired capacity for differentiation and muscle growth. Dr. Dhammageddy then explores the potential use of cytidine analogs, specifically azacytidine, to restore satellite cell function. He explains that these drugs can reduce DNA methylation and reactivate the myogenic potential of satellite cells. The potential pathways and genes involved in this process are also discussed. Dr. Dhammageddy concludes by suggesting that azacytidine could be used as a new therapeutic approach for children with cerebral palsy to improve muscle growth and function.

Keywords

muscle and motor dysfunction

children with cerebral palsy

activating resident muscles

muscle impairment

satellite cells

postnatal muscle development

muscle repair

cytidine analogs

azacytidine