May 2025 CME Activity: Systematic Review and Meta-Analysis of Radiofrequency Ablation for Morton's Neuroma: Outcomes and Predictors of Success-Systematic Review and Meta-Analysis of Radiofrequency Ablation for Morton's Neuroma: Outcomes and Predictors of Success

Systematic Review and Meta-Analysis of Radiofrequency Ablation for Morton's Neuroma: Outcomes and Predictors of Success

Pdf Summary

The systematic review and meta-analysis conducted by Rafael Llombart-Blanco and colleagues focused on evaluating the efficacy and safety of radiofrequency ablation for treating Morton’s neuroma, a painful condition affecting the nerve tissue of the foot. The study adhered to the PRISMA guidelines, incorporating data from eight studies involving a total of 237 patients.<br /><br />The results indicated that radiofrequency ablation substantially reduces pain in individuals with Morton's neuroma. At the final follow-up, 47.57% of participants achieved complete pain relief, while 83.4% experienced at least partial improvement. Only 16.4% reported no benefit. Various factors, such as the temperature of the radiofrequency application and the number of cycles, influenced the treatment's effectiveness. Higher temperatures of 85°C and fewer radiofrequency cycles were associated with better outcomes in reducing pain levels.<br /><br />Regarding safety, complications were minimal, with only a 2.1% incidence rate, and most complications resolved without significant interventions.<br /><br />Despite promising results, limitations exist due to the small number of studies and the lack of randomized controlled trials, which restricts the ability to draw definitive conclusions. Additionally, short follow-up periods limit insights into long-term outcomes. The study suggested further research to explore potential advantages more thoroughly and verify whether the observed improvements translate into meaningful clinical benefits over the long term.<br /><br />In conclusion, radiofrequency ablation shows promise as an effective and safe nonsurgical treatment option for Morton’s neuroma, offering significant pain relief. Further investigation through high-quality trials is needed to reinforce these findings and refine treatment protocols.

Keywords

Morton's neuroma

radiofrequency ablation

pain relief

efficacy

safety

meta-analysis

PRISMA guidelines

treatment outcomes

complications

clinical trials